The canalicular multispecific organic anion transporter (cMOAT), also termed MRP2, is a recently identified ATPbinding cassette transporter We previously established stable human cMOAT cDNAtransfected cells, LLC/cMOAT1 from LLCPK1 cells, and LLC/CMV cells that were transfected with an empty vectorAbstract We investigated the role of cMOAT/MRP2 (canalicular multispecific organic anion transporter/multidrug resistanceassociated protein 2) in the intestinal secretion of organic anions by comparing the behavior in SpragueDawley (SD) rats and Eisai hyperbilirubinemic rat (EHBR) whose cMOAT/MRP2 is hereditarily defectiveBackground Multidrug resistanceassociated protein (MRP) and canalicular multispecific organic anion transporter (cMOAT) are transporter proteins that pump organic anions across cellular membranes and have been linked to resistance to cytotoxic drugs
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Cmoat transporter
Cmoat transporter-Associated protein 2 (MRP2/cMOAT) is highly expressed in the bile canaliculus of hepatocytes and mediates hepatobiliary trans port of many organic compounds including GSH (16–19)Radiolabeled substrate was added to 50 mlof23reaction buffer ( mM MES/Tris, pH 80, 10 mM ATP, mM MgCl 2
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CMOAT abbreviation stands for Canalicular Multispecific Organic Anion TransporterCorrection to "Both cMOAT/MRP2 and another unknown transporter(s) are responsible for the biliary excretion of glucuronide conjugate of the nonpeptide angiotensin II antagonist, telmisaltan" Drug Metabolism and Disposition January 01, 29 (1) ;This transporter was originally known as the canalicular multispecific organic anion transporter (cMOAT), but it is now called MRP2 Its substrate specificity was defined in detail with the help of a rat strain (TR − /GY) lacking cMOAT
Ensembl ENSG ENSMUSG UniProt O Q9R1X5 RefSeq (mRNA) NM_ NM_0056 NM_ NM_ NM_1769 RefSeq (protein) NP_ NP_ NP_ NP_0318 NP_7809 Location (UCSC) Chr 3 192 – Mb Chr 16 33 – 43 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Multidrug resistanceassociated protein 5 is a proteinMultidrug resistanceassociated protein 2 (MRP2) also called canalicular multispecific organic anion transporter 1 (cMOAT) or ATPbinding cassette subfamily C member 2 (ABCC2) is a protein that in humans is encoded by the ABCC2 geneCorrection to "Both cMOAT/MRP2 and another unknown transporter(s) are responsible for the biliary excretion of glucuronide conjugate of the nonpeptide angiotensin II antagonist, telmisaltan" Drug Metabolism and Disposition January 01, 29 (1) ;
How is Canalicular Multispecific Organic Anion Transporter abbreviated?Background Multidrug resistanceassociated protein (MRP) and canalicular multispecific organic anion transporter (cMOAT) are transporter proteins that pump organic anions across cellular membranes and have been linked to resistance to cytotoxic drugsThe exporter ABCC2 (cMOAT, MRP2) is a membranebound protein on the apical side of enterocytes and hepatic biliary vessels that transports leukotriene C 4, glutathione, some conjugated bile salts, drugs, xenobiotics, and phytonutrients The latter class includes quercetin, a bioactive flavonoid found in foods such as onions, apples, tea, and wine
Pdf Drug Export Activity Of The Human Canalicular Multispecific Organic Anion Transporter In Polarized Kidney Mdck Cells Expressing Cmoat Mrp2 Cdna Semantic Scholar
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Associated protein 2 (MRP2/cMOAT) is highly expressed in the bile canaliculus of hepatocytes and mediates hepatobiliary trans port of many organic compounds including GSH (16–19)A human clone homologous to rat canalicular multispecific organic anion transporter (cMOAT) was found and designated human cMOAT Fluorescence in situ hybridization demonstrated the chromosomal locus of the gene on chromosome 10q24Etoposide transport kinetics were characterized in Caco2 cells and in well established MadinDarby canine kidney (MDCKII) cell lines that were stablytransfected with a human cDNA encoding Pglycoprotein (Pgp), human multidrug resistance protein (MRP1), or the canalicular multispecific organic anion (cMOAT) transporters to determine the roles of these transporters in etoposide efflux
Molecular Analysis Of The Massive Gsh Transport Mechanism Mediated By The Human Multidrug Resistant Protein 1 Abcc1 Scientific Reports
Frontiers The Relationship Between Actin Cytoskeleton And Membrane Transporters In Cisplatin Resistance Of Cancer Cells Cell And Developmental Biology
Multidrug resistance protein 2 (MRP2), also known as cMRP, cMOAT, and ABCC2, is an ATP binding cassette (ABC) transporter and part of the multidrug resistance (MRP) family The MRP proteins are membrane proteins that function as organic anion pumps involved in the cellular removal of cancer drugsWhat does CMOAT stand for?Etoposide transport kinetics were characterized in Caco2 cells and in well established MadinDarby canine kidney (MDCKII) cell lines that were stablytransfected with a human cDNA encoding Pglycoprotein (Pgp), human multidrug resistance protein (MRP1), or the canalicular multispecific organic anion (cMOAT) transporters to determine the roles of these transporters in etoposide efflux
Cisplatin Induces Renal Expression Of P Glycoprotein And Canalicular Multispecific Organic Anion Transporter American Journal Of Physiology Renal Physiology
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Oude Elferink et al 1990, 1995)The human cMOAT gene encodes a membrane protein involved in the ATPdependent transport of hydrophobic compounds To determine whether cMOAT is associated with drug sensitivity, we transfected an expression vector containing cMOAT antisense cDNA into the HepG2 human hepatic cancer cell lineThe major basolateral membrane transporter involved in renal Na and K exchange is the primary renal Na /K ATPase which is composed of the α 1 subunit encoded by the ATP1A1 gene and the β 1 subunit encoded by the ATP1B1 gene
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The canalicular multispecific organic anion transporter (cMOAT), a member of the ATPbinding cassette transporter family, mediates the transport of a broad range of nonbile salt organic anions from liver into bile cMOATdeficient Wistar rats (TR) are mutated in the gene encoding cMOAT, leading to defective hepatobiliary transport of a whole range of substrates, including bilirubin glucuronide These mutants also have impaired hepatobiliary excretion of GSH and, as a result, the bile flowA human clone homologous to rat canalicular multispecific organic anion transporter (cMOAT) was found and designated human cMOAT Fluorescence in situ hybridization demonstrated the chromosomal locus of the gene on chromosome 10q24Canalicular multispecific organic anion transporter (cMOAT/MRP2) is known to play a major role in the transport of anionic xenobiotics including many types of glucuronide and glutathione conjugates across the bile canalicular membrane
The Mrp2 Cmoat Transporter And Arsenic Glutathione Complex Formation Are Required For Biliary Excretion Of Arsenic Sciencedirect
The Human Atp Binding Cassette Abc Transporter Superfamily Journal Of Lipid Research
ATPbinding cassette (ABC) transporters are a large and ubiquitous superfamily of proteins in all living organisms from microbes to humans They translocate their substrates either in or out of the cells, by serving as importers and exporters, respectivelyABC proteins transport various molecules across extra and intracellular membranes ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN, White) This protein is a member of the MRP subfamily which is involved in multidrug resistance The specific function of this protein has not yet been determinedAliases ABC30, CMOAT, DJS, cMRP Gene name ATP binding cassette subfamily C member 2 (ABCC2) Summary The predicted membrane topology of MRP2 transporter includes 12 transmembrane domains with at least two substratebinding sites MRP2 localizes to the apical membrane domain of polarized cells such as hepatocytes, renal proximal tubule
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Canalicular multispecific organic anion transporter (cMOAT/MRP2) is known to play a major role in the transport of anionic xenobiotics including many types of glucuronide and glutathione conjugates across the bile canalicular membraneThe major basolateral membrane transporter involved in renal Na and K exchange is the primary renal Na /K ATPase which is composed of the α 1 subunit encoded by the ATP1A1 gene and the β 1 subunit encoded by the ATP1B1 geneMultidrug resistanceassociated protein (MRP) and canalicular multispecific organic anion transporter (cMOAT) are transporter proteins that pump organic anions across cellular membranes and have
Multidrug Resistance Associated Protein An Overview Sciencedirect Topics
Monitoring Protein Protein Interactions Between The Mammalian Integral Membrane Transporters And Pdz Interacting Partners Using A Modified Split Ubiquitin Membrane Yeast Two Hybrid System Molecular Cellular Proteomics
Here, presentation of the Chlamydomonas ABC transporter superfamily will be restricted to the members of the MRP and ATM/HMT subfamilies because members of these subfamilies contribute to metal transport in plants and S cerevisiaeMultidrug resistance protein 2 (MRP2), also known as cMRP, cMOAT, and ABCC2, is an ATP binding cassette (ABC) transporter and part of the multidrug resistance (MRP) family The MRP proteins are membrane proteins that function as organic anion pumps involved in the cellular removal of cancer drugsMRP2 (cMOAT / ABCC2) is expressed in many tissues and transports relatively hydrophilic drugs Drugs are excreted by MRP2 into bile from the liver and into the lumen of the small intestine or into urine from the kidney MRP2 may cause multidrug resistance and drugdrug interactions along with MDR1 and BCRP
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The MRP2/cMOAT transporter and arsenicglutathione complex formation are required for biliary excretion of arsenic Kala SV(1), Neely MW, Kala G, Prater CI, Atwood DW, Rice JS, Lieberman MW Author information (1)Departments of Pathology and Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas , USACMOAT stands for Canalicular Multispecific Organic Anion Transporter cMOAT is defined as Canalicular Multispecific Organic Anion Transporter frequentlyThis transporter was originally known as the canalicular multispecific organic anion transporter (cMOAT), but it is now called MRP2 Its substrate specificity was defined in detail with the help of a rat strain (TR − /GY) lacking cMOAT
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Multidrug resistanceassociated protein 2 (MRP2) also called canalicular multispecific organic anion transporter 1 (cMOAT) or ATPbinding cassette subfamily C member 2 (ABCC2) is a protein that in humans is encoded by the ABCC2 geneA human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatinresistant human cancer cell lines with decreased drug accumulation Cancer Res , 56 ( 1996 ) , pp 4124 4129Hepatobiliary excretion of conjugated bilirubin is mediated by an ATPdependent transport system, a canalicular multispecific organic anion transporter (cMOAT) (MIM ), in the apical (canalicular) membrane of hepatocytes (Kitamura et al 1990;
Functional Analysis Of A Canalicular Multispecific Organic Anion Transporter Cloned From Rat Liver Journal Of Biological Chemistry
Membrane Transporters And Drug Response
Multidrug resistanceassociated protein 2 (MRP2) also called canalicular multispecific organic anion transporter 1 (cMOAT) or ATPbinding cassette subfamily C member 2 (ABCC2) is a protein that in humans is encoded by the ABCC2 geneSeveral organic anions are excreted into the bile via a canalicular multispecific organic anion transporter (cMOAT), which is hereditarily defective in mutant rats, such as the Eisai hyperbilirubinHuman canalicular multispecific organic anion transporter (cMOAT/MRP2) also belongs to the ABC transporter superfamily and shows a 49% amino acid identity to human MRP1, Rat and rabbit cMOAT transport a GSH conjugate, leukotriene C 4 (LTC 4), which is a high affinity endogenous substrate for MRP1,,,
Homozygous Mutation Arg 768 Trp In The Abc Transporter Encoding Gene Mrp2 Cmoat Abcc2 Causes Dubin Johnson Syndrome In A Caucasian Patient Journal Of Human Genetics
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What is the abbreviation for Canalicular Multispecific Organic Anion Transporter?The canalicular multispecific organic anion transporter, cMoat, is an ATPbindingcassette protein expressed in the canalicular domain of hepatocytes In addition to the transport of endo and xenobiotics, cMoat has also been proposed to transport GSH into bile, the major driving force of bileacidindependent bile flowRecently, Paulusma et al demonstrated that rat cMOAT is a liverspecific homolog of the MRP;
Functional Analysis Of A Canalicular Multispecific Organic Anion Transporter Cloned From Rat Liver Sciencedirect
Multidrug Resistance Associated Protein 2 Wikipedia
The most extensively studied member of this family is cMOAT, the canalicular Multispecific Organic Anion Transporter The substrate specificity of this pump was originally defined by an inborn error in rats, lacking this protein These rats are mildly hyperbilirubinemic, because of their inability to secrete bilirubin glucuronides into their bileThey reported that TR − rats, an animal model of DJS, are defective in anion transporter (cMOAT) and found a single nucleotide deletion mutation at nucleotide 1179 in the gene, resulting in reduced mRNA abundance and absence of the protein (10)ATPbinding cassette (ABC) transporters are a large and ubiquitous superfamily of proteins in all living organisms from microbes to humans They translocate their substrates either in or out of the cells, by serving as importers and exporters, respectively
Identification Of The Apical Membrane Targeting Signal Of The Multidrug Resistance Associated Protein 2 Mrp2 Cmoat Journal Of Biological Chemistry
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Overall, the current study suggests that Pgp and cMOAT are capable of mediating the efflux of CPT11 in vitro Since both Pgp and cMOAT are expressed in the intestine, liver, and kidney, it is likely that these efflux transporters play a significant role limiting the oral absorption and disposition of this important anticancer drugMultidrug resistanceassociated protein (MRP) and the canalicular multispecific organic anion transporter (cMOAT) are organic anion pumps that have been linked to cytotoxic drug resistance We previously reported the isolation of three human MRP/cMOATrelated transporters, MOATB (MRP4), MOATC (MRP5) and MOATD (MRP3)Overall, the current study suggests that Pgp and cMOAT are capable of mediating the efflux of CPT11 in vitro Since both Pgp and cMOAT are expressed in the intestine, liver, and kidney, it is likely that these efflux transporters play a significant role limiting the oral absorption and disposition of this important anticancer drug
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Abstract We investigated the role of cMOAT/MRP2 (canalicular multispecific organic anion transporter/multidrug resistanceassociated protein 2) in the intestinal secretion of organic anions by comparing the behavior in SpragueDawley (SD) rats and Eisai hyperbilirubinemic rat (EHBR) whose cMOAT/MRP2 is hereditarily defectiveMultispecific Organic Anion Transporter Is Responsible for the Biliary Excretion of the Camptothecin Derivative Irinotecan and its Metabolites in Rats XiaoYan Chu, Yukio Kato, Kayoko Niinuma, KenIchi Sudo, Hideo Hakusui and Yuichi Sugiyama Journal of Pharmacology and Experimental Therapeutics April 1997, 281 (1) ;Transport Assays—ATPdependent transport of 3HDNPSG and BA was measured by the standard vesicle filtration assay Transport by secretory vesicles was determined as described previously (23) Vacuolar transport was measured as follows;
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The Mrp2 Cmoat Transporter And Arsenic Glutathione Complex Formation Are Required For Biliary Excretion Of Arsenic Sciencedirect
Organic anion transporter (cMOAT), located in the apical (canalicular) membrane of hepatocytes ( 5–7) The multidrug resistanceassociated protein (MRP) can also transport glutathione conjugates leucotriene C 4 (LTC ) and dinitrophenyl glutathione (GSDNP) (8,9), which are also putative substrates for transport by cMOAT
Expression Of Multidrug Resistance Protein 3 Multispecific Organic Anion Transporter D In Human Embryonic Kidney 293 Cells Confers Resistance To Anticancer Agents Cancer Research
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