The canalicular multispecific organic anion transporter (cMOAT), also termed MRP2, is a recently identified ATPbinding cassette transporter We previously established stable human cMOAT cDNAtransfected cells, LLC/cMOAT1 from LLCPK1 cells, and LLC/CMV cells that were transfected with an empty vectorAbstract We investigated the role of cMOAT/MRP2 (canalicular multispecific organic anion transporter/multidrug resistanceassociated protein 2) in the intestinal secretion of organic anions by comparing the behavior in SpragueDawley (SD) rats and Eisai hyperbilirubinemic rat (EHBR) whose cMOAT/MRP2 is hereditarily defectiveBackground Multidrug resistanceassociated protein (MRP) and canalicular multispecific organic anion transporter (cMOAT) are transporter proteins that pump organic anions across cellular membranes and have been linked to resistance to cytotoxic drugs
Abc Of Oral Bioavailability Transporters As Gatekeepers In The Gut Gut